JNCI J NatlCancer Inst(2017) 109(9): djx014doi: 10.1093/jnci/djx014Firstpublished online March 31, 2017Co-activation of STAT3 and YES-Associated Protein1 (YAP1) Pathway in EGFR-Mutant NSCLC本文的主題是信號轉導與轉錄激活因子(signaltransducer and activator of transcription 3 ,STAT3) 和Src-YES相關蛋白(Src-YES-associatedprotein 1,YAP1)是2個EGFR TKI 治療期間激活并限制了EGFR TKI 治療的信號通路.本文發現肺癌細胞在開始EGFR 抑制劑治療通過激活STAT3和Src-YAP1信號通路而生存. 聯合EGFR, STAT3,和Src協同治療